𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An alternative algorithm for incorporating the relationships between animals in estimating variance components

✍ Scribed by R. Mrode; R. Thompson

Book ID
115142720
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
248 KB
Volume
106
Category
Article
ISSN
0931-2668

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Both a mixture likelihood method and the EM algorithm are implemented to estimate the time-toonset-of and the time-to-death-from the tumor of interest in animal carcinogenicity studies. Both methods are implemented using Box's Complex Method for ΓΏnding the maximum likelihood estimates of parameters