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An allosteric modulator to control endogenous G protein-coupled receptors with light

✍ Scribed by Pittolo, Silvia; Gómez-Santacana, Xavier; Eckelt, Kay; Rovira, Xavier; Dalton, James; Goudet, Cyril; Pin, Jean-Philippe; Llobet, Artur; Giraldo, Jesús; Llebaria, Amadeu; Gorostiza, Pau


Book ID
126267476
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
796 KB
Volume
10
Category
Article
ISSN
1552-4450

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## Abstract The cannabinoid CB~1~ receptor is a class A G protein‐coupled receptor (GPCR) that is the most widely expressed GPCR in the brain. Many GPCRs contain allosteric binding sites for endogenous and/or synthetic ligands, which are topographically distinct from the agonist‐binding site that i