An allosteric crown ether-induced activity control for the cleavage of a phosphodiester bond

✍ Scribed by Tomokazu Tozawa; Sumio Tokita; Yuji Kubo

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 125 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00601-9

✦ Synopsis

Bis (thiourea) receptor 1 based on a highly flexible dibenzo-diaza-30-crown-10 scaffold represented a K + -organized microenvironment to markedly accelerate the cleavage of the phoshodiester linkage of the RNA model substrate (2-hydroxypropyl-p-nitrophenyl phosphate).