An allelotype of papillary thyroid cancer

✍ Scribed by Joseph A. Califano; Michael M. Johns III; William H. Westra; Miriam N. Lango; David Eisele; Motoyasu Saji; Martha A. Zeiger; Robert Udelsman; Wayne M. Koch; David Sidransky

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 336 KB
• Volume: 69
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19961220)69:6<442::aid-ijc3>3.0.co;2-4

✦ Synopsis

Although papillary carcinoma accounts for approximately 70% of all thyroid cancers, preliminary studies of allelic loss have thus far not identified any areas of chomosomal deletion. We evaluated 30 papillary thyroid carcinomas for chromosomal loss/allelic imbalance by testing at least 2 microsatellite markers from every autosomal arm. Fifteen of the 30 tumors tested exhibited loss of heterozygosity/allelic imbalance (LOH/AI) at one or more loci. Chromosomal arms with frequent LOH/AI included 4q, Sp, 7p and I I p. An average of I. I chromosomal arms displayed LOH/AI in each individual tumor. Therefore, 4q, 5p, 7p and, to a lesser extent, I I p display significant LOH/AI in papillary thyroid cancer, which indicates the presence of putative tumor-suppressor gene loci at these chromosomal arms.