✦ LIBER ✦
An alkaloidal extract (ALKS1) from Trophis racemosa lowers intraocular pressure in dogs
✍ Scribed by Maxine D. Gossell-Williams; Manley E. West; Oswald Simon
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 30 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
No coin nor oath required. For personal study only.
✦ Synopsis
A 1.0% solution of ALKS1, an alkaloidal extract obtained from Trophis racemosa, produced a significant fall in intraocular pressure in the dog's eye (p < 0.001). The fall was antagonized by atropine (p < 0.0025), suggesting ALKS1 is acting through a muscarinic mode of action. Further purifcation of the extract is required to determine the actual compound producing this effect on the eye.