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An Additive Genetic Gamma Frailty Model for Linkage Analysis of Diseases with Variable Age of Onset Using Nuclear Families

✍ Scribed by Hongzhe Li


Book ID
110396151
Publisher
Springer
Year
2002
Tongue
English
Weight
162 KB
Volume
8
Category
Article
ISSN
1380-7870

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## Abstract Few models for segregation (or combined segregation‐linkage) analysis have been developed to account for variable age of onset. The unified model (UM) can only take into account age at examination. In the logistic hazard model (LHM), Abel and Bonney ([1990] Genet. Epidemiol. 7:391–407)