We use frailty models to analyse the e!ect of latent genetic and environmental risk factors on hazard functions in nuclear families. The approach expresses latent risk factors (frailties) as functions of the e!ects of a single major gene and shared familial risk. The latter may result from shared po
β¦ LIBER β¦
An Additive Genetic Gamma Frailty Model for Linkage Analysis of Diseases with Variable Age of Onset Using Nuclear Families
β Scribed by Hongzhe Li
- Book ID
- 110396151
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 162 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1380-7870
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## Abstract Few models for segregation (or combined segregationβlinkage) analysis have been developed to account for variable age of onset. The unified model (UM) can only take into account age at examination. In the logistic hazard model (LHM), Abel and Bonney ([1990] Genet. Epidemiol. 7:391β407)