An active site of growth hormone for eliciting the differentiation of preadipose 3T3-F442A cells to adipose cells
β Scribed by Eriko Uchida; Seitaro Shimokawa; Yoshitaka Nishida; Hisashi Takasu; Morio Ikehara; Seiichi Uesugi; Ken-ichi Tomita; Akira Tanaka; Minoru Morikawa; Takao Hayakawa; Satoshi Nishikawa
- Book ID
- 117054959
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 484 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Cultured preadipose 3T3 cells undergo a process of differentiation in which they convert to adipose cells. Growth hormone promotes this conversion. Since 3T3 sublines vary in their susceptibility to adipose conversion, it was of interest to examine the properties of the growth hormone r
## Abstract Preβadipose 3T3βF442A cells exposed to fetal bovine serum or human growth hormone (adipogenic medium) become irreversibly committed to differentiation into adipocytes within 24β36 h. We show now that the action of the serineβthreonine kinase inhibitor staurosporine is much more rapid si