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An activator of cerebroside sulphatase in human normal liver and in cases of congenital metachromatic leukodystrophy

โœ Scribed by Horst Jatzkewitz; Klaus Stinshoff

Book ID
115904001
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
294 KB
Volume
32
Category
Article
ISSN
0014-5793

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Genetic complementation in somatic cell
Genetic complementation in somatic cell hybrids of cerebroside sulfatase activator deficiency and metachromatic leukodystrophy fibroblasts
โœ H. Kihara; Katherine K. Tsay; A. L. Fluharty ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Springer ๐ŸŒ English โš– 241 KB

Several cases of metachromatic leukodystrophy (MLD) have been described with normal or near normal activities of arylsulfatase A (cerebroside sulfatase). However, the ability of intact cultured fibroblasts to hydrolyze cerebroside sulfate was impaired. Since the impairment was corrected by cerebrosi