𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis

✍ Scribed by Osamu Abe; Haruyasu Yamada; Yoshitaka Masutani; Shigeki Aoki; Akira Kunimatsu; Hidenori Yamasue; Rinmei Fukuda; Kiyoto Kasai; Naoto Hayashi; Tomohiko Masumoto; Harushi Mori; Tsutomu Soma; Kuni Ohtomo

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
180 KB
Volume
17
Category
Article
ISSN
0952-3480

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The purpose of this study is to investigate whether the diffusional anisotropy of water molecules is disrupted in the pyramidal and extra‐pyramidal regions in patients with amyotrophic lateral sclerosis (ALS). We studied seven patients with probable ALS (four women, mean age ± SD, 57.3 ± 6.2 years old) according to the criteria of the World Federation of Neurology. A control group consisted of 11 age‐ and sex‐matched volunteers (six women, 57.1 ± 4.5) without disorders affecting the central nervous system. Voxel‐based diffusion tensor analysis was made with statistical parametric mapping (SPM99). We also created the normalized corticospinal tractography from the diffusion tensor data. The significant fractional anisotropy (FA) decrease in the ALS group was found in the right frontal subgyral white matter and left frontal precentral white matter. These clusters with significant FA decrease corresponded well to the average group map of the corticospinal tract in a standard reference frame. These results suggested that the combination of voxel‐based diffusion tensor analysis and diffusion tensor tractography might help determine the location of the affected neuronal tissues among ALS patients in a non‐invasive manner. Copyright © 2004 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Quantitative diffusion tensor imaging in
Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: Revisited
✍ Caroline A. Sage; Wim Van Hecke; Ronald Peeters; Jan Sijbers; Wim Robberecht; Pa 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 777 KB

## Abstract Voxel‐based analyses (VBA) are increasingly being used to detect white matter abnormalities with diffusion tensor imaging (DTI) in different types of pathologies. However, the validity, specificity, and sensitivity of statistical inferences of group differences to a large extent depend

Voxel-based morphometry study of brain v
Voxel-based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability
✍ F. Agosta; E. Pagani; M.A. Rocca; D. Caputo; M. Perini; F. Salvi; A. Prelle; M. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

## Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive and simultaneous degeneration of upper and lower motor neurons. The pathological process associated to ALS, albeit more pronounced in the motor/premotor cortices and along the corticospin

Abnormal diffusion tensor in nonsymptoma
Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation
✍ Man-Cheuk Ng; Jenny Ting Ho; Shu-Leong Ho; Raymand Lee; Geng Li; Tat-Sun Cheng; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

## Abstract ## Purpose To determine whether diffusion abnormalities can be observed in nonsymptomatic family members with a known causative Cu/Zn superoxide dismutase mutation (asymptomatic familial amyotrophic lateral sclerosis; AFALS^+SOD1^) in a family with autosomal dominant familial amyotroph

Nerve conduction velocities of single th
Nerve conduction velocities of single thenar motor axons based on the automated analysis of F waves in amyotrophic lateral sclerosis
✍ Kevin J. Felice 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB 👁 2 views

The motor unit number estimate (MUNE), motor unit size, and conduction velocity (CV) of thenar surface-recorded motor unit action potentials (S-MUAPs) as collected by the automated F-wave technique were analyzed in 13 patients with amyotrophic lateral sclerosis (ALS) (aged 29-78 years, mean: 61) and