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Amyotrophic lateral sclerosis and neurosarcoidosis: A case report

✍ Scribed by I-Hweii Amy Chen; Hiroshi Mitsumoto; Jean P. Vonsattel; Arthur P. Hays

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
256 KB
Volume
39
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

Amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis without definable biomarkers. The pathomechanism of motor neuron degeneration in ALS has yet to be elucidated. Here we present a case of limb‐onset ALS, with autopsy findings of Bunina bodies and skein‐like inclusions, as well as sarcoid granulomas predominating among motor neurons. The targeting of the motor neurons by the sarcoid inflammation raises questions regarding the role of cellular immunity in the pathomechanisms for ALS. Muscle Nerve, 2009

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