Amyotrophic Lateral Sclerosis

✍ Scribed by M. Maurer

• Publisher: Intech
• Year: 2011
• Tongue: English
• Leaves: 738
• Category: Library

✦ Table of Contents

00_preface_Amyotrophic Lateral Sclerosis......Page 1
00x_part1......Page 21
01_Amyotrophic Lateral Sclerosis:
An Introduction to Treatment and Trials......Page 23
02_Insights Arising from Gene Expression Profiling
in Amyotrophic Lateral Sclerosis......Page 61
03_Dynamic Meta-Analysis as a Therapeutic
Prediction Tool for Amyotrophic
Lateral Sclerosis......Page 79
04_In Vivo and In Vitro Models to Study Amyotrophic Lateral Sclerosis......Page 101
05_Advantages and Pitfalls in
Experimental Models Of ALS......Page 145
06_Electrophysiological Abnormalities in SOD1
Transgenic Models in Amyotrophic Lateral
Sclerosis: The Commonalities and Differences......Page 177
07_Molecular and Electrical Abnormalities in the
Mouse Model of Amyotrophic Lateral Sclerosis......Page 195
07x_part2......Page 215
08_Role of Mitochondrial Dysfunction in Motor
Neuron Degeneration in ALS......Page 217
09_Role of Neuronal Mitochondrial Metabolic
Phenotype in Pathogenesis of ALS......Page 245
10_Mutant Cu/Zn-Superoxide Dismutase Induced
Mitochondrial Dysfunction in Amyotrophic
Lateral Sclerosis......Page 269
11_Folding and Aggregation of
Cu, Zn-Superoxide Dismutase......Page 285
12_Oxidative Modifications of Cu, Zn-Superoxide
Dismutase (SOD1) – The Relevance to
Amyotrophic Lateral Sclerosis (ALS)......Page 321
13_Reactive Nitrogen Species in
Motor Neuron Apoptosis......Page 333
14_Protein Aggregates in Pathological Inclusions
of Amyotrophic Lateral Sclerosis......Page 355
15_The Kynurenine Pathway......Page 377
15x_part3......Page 395
16_The Astrocytic Contribution in ALS:
Inflammation and Excitotoxicity......Page 397
17_Innate Immunity in ALS......Page 413
18_The Role of TNF-Alpha in ALS: New Hypotheses
for Future Therapeutic Approaches......Page 433
19_Stem Cell Application for Amyotrophic
Lateral Sclerosis: Growth Factor
Delivery and Cell Therapy......Page 457
20_Glial Cells as Therapeutic Targets for ALS......Page 475
20x_part4......Page 497
21_Genetics of Amyotrophic Lateral Sclerosis......Page 499
22_Genetics of Familial
Amyotrophic Lateral Sclerosis......Page 537
23_A Major Genetic Factor at Chromosome 9p
Implicated in Amyotrophic Lateral Sclerosis
(ALS) and Frontotemporal Lobar Degeneration
(FTLD)......Page 557
23x_part5......Page 575
24_Multidisciplinary Rehabilitation in
Amyotrophic Lateral Sclerosis......Page 577
25_Assessment and Management of Respiratory
Dysfunction in Patients with Amyotrophic
Lateral Sclerosis......Page 599
26_Nutritional Care in Amyotrophic Lateral
Sclerosis: An Alternative for the Maximization of
the Nutritional State......Page 615
27_How to Assess Disease’s Severity and Monitor
Patients with Amyotrophic Lateral Sclerosis:
Lessons From Neurophysiology......Page 633
28_Protection of Motor Neurons in
Pre-Symptomatic Individuals Carrying SOD 1
Mutations: Results of Motor Unit Number
Estimation (MUNE) Electrophysiology......Page 647
29_Communication Impairment in ALS Patients
Assessment and Treatment......Page 685
30_Human Computer Interactions for Amyotrophic
Lateral Sclerosis Patients......Page 703
31_Overview of Cognitive Function in ALS, with
Special Attention to the Temporal Lobe:
Semantic Fluency and Rating the
Approachability of Faces
......Page 723