Amyloidosis in behçet's syndrome

✍ Scribed by Sebahattin Yurdakul; Nüket Tüzüner; Ibrahim Yurdakul; Vedat Hamuryudan; Hasan Yazici

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 350 KB
• Volume: 33
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780331019

✦ Synopsis

We investigated the frequency of amyloidosis in 99 consecutive patients (65 men and 34 women) with Behqet's syndrome. Rectal biopsies performed on all patients showed no amyloidosis by polarizing microscopy. The results of urinalyses were normal in all patients. Among 1,130 patients registered in our Behcet's syndrome outpatient clinic, 5 were found to have systemic amyloidosis, all of the AA type.

Although secondary amyloidosis is a well established complication in some chronic inflammatory disorders (e.g., rheumatoid arthritis and ankylosing spondylitis) (1,2), it seems to be infrequent in Behget's syndrome. The evidence for amyloidosis in Behget's syndrome is derived primarily from case reports or compiled series. A total of 24 patients with amyloidosis were reviewed recently (3). In a previous survey, we found no amyloidosis among 30 consecutive patients with BehCet's syndrome (4). In the present study, we expanded our survey to 99 patients (65 men and 34 women). In addition, we reviewed the medical records of 1,130 outpatients at our multdisiciplinary From the Departments of Medicine (