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Amyloid-β proteins activate Ca2+-permeable channels through calcium-sensing receptors

✍ Scribed by Chianping Ye; Chrystal L. Ho-Pao; Marie Kanazirska; Steven Quinn; Kimberly Rogers; Christine E. Seidman; J.G. Seidman; Edward M. Brown; Peter M. Vassilev


Book ID
101244424
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
163 KB
Volume
47
Category
Article
ISSN
0360-4012

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Regulation of a Ca2+-activated K+ channe
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## Abstract By using pharmacological and molecular approaches, we previously showed that the G‐protein‐coupled, extracellular calcium (Ca)‐sensing receptor (CaR) regulates a large‐conductance (∼140 pS), Ca^2+^‐activated K^+^ channel [I~K(Ca)~; CAKC] in U87 astrocytoma cells. Here we show that eleva