## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st
Amyloid β protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo
✍ Scribed by Jing-Yan Meng; Hiroaki Kataoka; Hiroshi Itoh; Masashi Koono
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 667 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The antineoplastic effects of combinations of anticancer drugs (5‐fluorouracil, irinotecan and cisplatin) and triterpenes (ursolic acid, betulinic acid, oleanolic acid and a Japanese apricot extract (JAE) containing triterpenes) on esophageal squamous carcinoma cells were examined by th
Autocrine transforming growth factor a (TGFa) activity and control mechanisms for its expression were examined in a representative clonal isolate (CBS4) of a well-differentiated human colon carcinoma cell line designated CBS. CBS4 cells expressed TGFa and its receptor, epidermal growth factor recept
## Abstract Transforming growth factor‐β (TGF‐β) inhibits epithelial cell proliferation. Inactivation of the TGF‐β signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF‐β receptors or TGF‐β1 expression and the clinicopathologic characte
We examined the effect of the stable transfection of latent TGF-1 cDNA, under the control of a cytomegalovirus promoter in the expression vector pcDNA3, into a 4NQOinduced clonal rat oral keratinocyte cell line that formed undifferentiated spindle cell tumours following subcutaneous transplantation
## Abstract Flavonoids from fruits and vegetables probably reduce risks of diseases associated with oxidative stress, including cancer. Apples contain significant amounts of flavonoids with antioxidative potential. The objectives of this study were to investigate such compounds for properties assoc