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Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)

✍ Scribed by Dr. D. M. A. Mann; T. Iwatsubo; N. J. Cairns; P. L. Lantos; D. Nochlin; S. M. Sumi; T. D. Bird; P. Poorkaj; J. Hardy; M. Hutton; G. Prihar; R. Crook; M. N. Rossor; M. Haltia

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
893 KB
Volume
40
Category
Article
ISSN
0364-5134

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✦ Synopsis

Amyloid f3 protein (AD) deposition was investigated in the frontal cortex of 8 cases of (genetically confirmed) chromosome 14-linked Alzheimer's disease (AD) using the end-specific monoclonal antibodies BA27 and BC05 to detect the presence of AP4,, and AfL,2(431, respectively. In all patients, AP42(43) was the predominant peptide species present. The total amount of AD40 and AP42(431 deposited was more than twice the amount deposited in cases of sporadic AD of similar disease duration, although the ratio between the extent of AD40 and A(342(43) deposition was unaltered, compared with sporadic AD. Therefore, (one of) the effects of the mutations in the presenilin 1:PS-1 (S182) gene may be to cause or at least promote an early and excessive deposition of AP*2(43) within the brain, a property shared with other inherited forms of AD, such as those due to amyloid precursor protein mutations, and Down's syndrome (trisomy 21).

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