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Amyloid β peptides with an additional cysteine residue can enhance immunogenicity and reduce the amyloid β burden in an Alzheimer’s disease mouse model

✍ Scribed by Jun-ichi Matsuda; Kazuyoshi Kaminaka; Chikateru Nozaki

Book ID: 116298325
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 156 KB
Volume: 382
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.02.153

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Background One of the pathological hallmarks of Alzheimer's disease (AD) is deposits of amyloid β-peptide (Aβ) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with Aβ reduces Aβ deposits and improves memory and learning deficits. Because recent clinical trials of immunizati