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Amyloid β-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor

✍ Scribed by Yasuaki Goto; Tetsuhiro Niidome; Akinori Akaike; Takeshi Kihara; Hachiro Sugimoto


Book ID
116293807
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
790 KB
Volume
351
Category
Article
ISSN
0006-291X

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## Abstract Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular Ca^2+^ homeostasis. In addition, it was shown that an endoplasmic reticulum (ER)‐specific apoptotic pat