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Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)

✍ Scribed by Goar Gevorkian; Alfonso Gonzalez-Noriega; Gonzalo Acero; Jorge Ordoñez; Colette Michalak; Maria Elena Munguia; Tzipe Govezensky; David H. Cribbs; Karen Manoutcharian


Book ID
116765129
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
440 KB
Volume
52
Category
Article
ISSN
0197-0186

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Regulation of microtubule-associated pro
✍ Xun Mei; Andrew J. Sweatt; James A. Hammarback 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

The MAP1B and MAP1A genes each produce an mRNA that encodes a polyprotein. When cleaved, each polyprotein yields a single heavy chain and a single light chain, which become noncovalently associated. In previous work, it was found that the MAP1B light chains and heavy chains exist in a 2:1 ratio. Thr