## Abstract Research on the molecular pathogenesis of Alzheimer's disease (AD) has made great strides over the last decade. This progress is the result of protein chemical analysis of two extracellular and intracellular fibrillary lesions in AD brain conducted during the 1980s, which identified β‐a
✦ LIBER ✦
Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
✍ Scribed by Ittner, Lars M.; Götz, Jürgen
- Book ID
- 109963192
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 363 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1471-0048
- DOI
- 10.1038/nrn2967
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## Abstract ## Objective Olfactory dysfunction is common in Alzheimer disease (AD) and other neurodegenerative diseases. Paired helical filament (PHF)‐tau, α‐synuclein, and amyloid‐β lesions occur early and severely in cerebral regions of the olfactory system, and they have also been observed in o