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Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway

✍ Scribed by Keita Takahashi; Tetsuhiro Niidome; Akinori Akaike; Takeshi Kihara; Hachiro Sugimoto


Book ID
111181490
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
910 KB
Volume
109
Category
Article
ISSN
0022-3042

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## Abstract Astrocytes are essential cells for maintaining brain integrity. We have recently shown that the transcription factor C/EBP homologous protein (CHOP), associated with endoplasmic reticulum (ER) stress, plays a key role in the astrocyte death induced by ischemia. Meanwhile, mediators of a