Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene
✍ Scribed by Botto, Marina; Hawkins, Philip N.; Bickerstaff, Maria C.M.; Herbert, Jeff; Bygrave, Anne E.; Mcbride, Alan; Hutchinson, Winston L.; Tennent, Glenys A.; Walportz, Mark J.; Pepys, Mark B.
- Book ID
- 109929860
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 477 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1078-8956
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To analyze the regulation of human serum amyloid P component (SAP) gene expression, we have produced seven transgenic mice. The 3.3 kb human SAP genes containing about 0.8 kb of 5' and 1.5 kb of 3' flanking region were injected into fertilized eggs of C57BL/6 mice. In five of the seven transgenic mi
## Abstract ## Objective To evaluate the regulation of acute‐phase serum amyloid A (A‐SAA) production in inflamed synovial tissue, and to elucidate a possible pathophysiologic role in the induction of matrix metalloproteinase (MMP) release by fibroblast‐like synoviocytes (FLS). ## Methods Synovi