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Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms

✍ Scribed by Desmond T. Walsh; Rosa M. Montero; Laura G. Bresciani; Angela Y.T. Jen; Pascale D. Leclercq; Debbie Saunders; Ahmed N. EL-Amir; Lukemann Gbadamoshi; Stephen M. Gentleman; Ling-Sun Jen

Book ID
115641703
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
254 KB
Volume
10
Category
Article
ISSN
0969-9961

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## Abstract Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid‐β peptides (Aβ). Aβ binding to the 75‐kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Aβ causes cell death in neuronal hybrid cells transf