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Amylin-mediated reduction in insulin sensitivity corresponds to reduced insulin receptor kinase activity in the rat in vivo

✍ Scribed by Michael Bryer-Ash; Lezley Follett; Norman Hodges; Sunil Wimalawansa

Book ID
116031321
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
949 KB
Volume
44
Category
Article
ISSN
1532-8600

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Amylin is a polypeptide of 37 amino acids, predominantly synthesized in pancreatic Beta cells. The peptide was suggested to be dysregulated in Type 2 (non-insulin-dependent) diabetes mellitus and it antagonized certain actions of insulin in vitro in rat muscle. This led to speculation that amylin is