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Amylin inhibits glucose-induced insulin secretion in a dose-dependent manner. Study in the perfused rat pancreas

✍ Scribed by Pilar Dégano; Ramona A. Silvestre; Mercedes Salas; Elena Peiró; José Marco


Book ID
119118152
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
414 KB
Volume
43
Category
Article
ISSN
0167-0115

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The isolated perfused rat pancreas was stimulated sequentially with arginine or glucose to analyze the time-dependent modulation of insulin release. A 10-min perfusion with arginine (5.0 mmol/l) induced 75% inhibition of the insulin response to repeated arginine stimulation 10 min later. When glucos