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Amsacrine is safe in patients with ventricular ectopy

✍ Scribed by Carmelo A. Puccio; Eric J. Feldman; Zalmen A. Arlin

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
184 KB
Volume
28
Category
Article
ISSN
0361-8609

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✦ Synopsis

Amsacrine is an active antileukemic agent known to induce cardiac arrhythmias, although the incidence of these cardiac events is low. Rhythm abnormalities associated with amsacrine use include the development of fatal tachyarrhythmias, but this risk can be minimized by ensuring a normal serum potassium level prior to drug administration. Even though amsacrine has been given safely to patients with preexisting supraventricular arrhythmias, its safety in patients with ventricular ectopy has not been addressed. We describe two patients who underwent treatment with amsacrine without developing life-threatening dysrhythmias and show that ventricular ectopy does not contraindicate therapy with this agent.

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