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Amplified Centrosomes in Breast Cancer: A Potential Indicator of Tumor Aggressiveness

✍ Scribed by Antonino B. D'Assoro; Susan L. Barrett; Christopher Folk; Vivian C. Negron; Kelly Boeneman; Robert Busby; Clark Whitehead; Franca Stivala; Wilma L. Lingle; Jeffrey L. Salisbury

Book ID: 110349694
Publisher: Springer US
Year: 2002
Tongue: English
Weight: 316 KB
Volume: 75
Category: Article
ISSN: 0167-6806
DOI: 10.1023/a:1016550619925

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## Abstract The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain‐containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF‐β tumor suppressor pathway. To characterize the role of __WWP1__ in breas