Gene amplification refers to a genomic change that results in an increased dosage of the gene(s) affected. Amplification represents one of the major molecular pathways through which the oncogenic potential of proto-oncogenes is activated during tumorigenesis. The architecture of amplified genomic st
Amplification of cellular oncogenes in cancer cells
β Scribed by Alitalo, Kari
- Book ID
- 123442626
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 449 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0968-0004
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## Abstract Studies of amplification and/or overexpression of cβmyc, HERβ2/neu, and Hβras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in bre
Alterations in the gene copy numbers of the proto-oncogenes HERZ/neu and c-myc in primary human breast cancer investigated in 73 patients. We detected amplification of Hβ¬R2/ neu in 17 patient samples and amplification of c-myc in I I, while amplification of both was seen in 6 samples. There was no c