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Amplification of 19q13.1–q13.2 sequences in ovarian cancer: G-band, FISH, and molecular studies

✍ Scribed by Floyd H. Thompson; Mark A. Nelson; Jeffrey M. Trent; Xin-Yuan Guan; Yun Liu; Jin-Ming Yang; Julia Emerson; Laurence Adair; Julie Wymer; Celia Balfour; Kathy Massey; Ronald Weinstein; David S. Alberts; Raymond Taetle

Book ID: 113253680
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 830 KB
Volume: 87
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(95)00248-0

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## Abstract The chromosomal region 11q13 is amplified in 15–20% of breast cancers; an event not only associated with estrogen receptor (ER) expression but also implicated in resistance to endocrine therapy. Coamplifications of the 11q13 and 8p12 regions are common, suggesting synergy between the am