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Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer

✍ Scribed by Soder, Anja I; Hoare, Stacey F; Muir, Sharon; Going, James J; Parkinson, E Kenneth; Keith, W Nicol

Book ID
110060683
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
681 KB
Volume
14
Category
Article
ISSN
0950-9232

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Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. While telomerase is undetectable in most normal somatic tissues, telomerase activation has been detected by a polymerase chain reaction (PCR)-based assay (TRAP) in many immortal cell lines and various cancers, incl