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Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas

✍ Scribed by Didier Ferbus; Aude Fléchon; Martine Muleris; Yong Li; Samir Hanash; Benoît Terris; Pascal Hammel; Laurence Pibouin; Bernard Dutrillaux; Gérard Goubin

Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
110 KB
Volume
80
Category
Article
ISSN
0020-7136

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✦ Synopsis

The OZF gene encodes a protein consisting of 10 zinc finger motifs and is located on chromosome 19q13.1. We report here the amplification and over-expression of the OZF gene in pancreatic carcinomas. Increased gene copy number was detected in 3 of 12 tumour cell lines and 2 of 12 primary pancreatic carcinomas. Expression was detected in all cell lines, and the gene was over-expressed in cell lines with OZF gene amplification. Five of 8 tumours, including 2 primary tumours with OZF gene amplification, displayed high levels of OZF protein, whereas normal pancreas expressed low levels. Immuno-histochemical analysis showed that expression was restricted to tumour cells. Thus, high-level expression of OZF is frequent in pancreatic carcinomas and may contribute to the development or progression of this tumour. Int.

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