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Amplification and nucleotide sequence of the quinolone resistance-determining region in the gyrA gene of mycobacteria

✍ Scribed by Emmanuelle Cambau; Wladimir Sougakoff; Vincent Jarlier

Book ID
109319801
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
498 KB
Volume
116
Category
Article
ISSN
0378-1097

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## Abstract We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinolone–gyrase interaction remain unclea