Amplification and expression of the c-myc oncogene in human lung cancer cell lines
โ Scribed by Little, Cameron D.; Nau, Marion M.; Carney, Desmond N.; Gazdar, Adi F.; Minna, John D.
- Book ID
- 109732657
- Publisher
- Nature Publishing Group
- Year
- 1983
- Tongue
- English
- Weight
- 371 KB
- Volume
- 306
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/306194a0
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Lung cancer i s a major cause of mortality in the United States and accounts for the majority of all cancer deaths in both men and women. It is hoped that through broadening our understanding of the mechanisms involved in transformation of bronchial epithelial cells we will be able to improve method
We identified 126 tumor cell lines established from patients with small cell cancer at the NCI-Navy Medical Oncology Branch from 1977 through 1992. Extensive clinical information was available on 96 patients from whom these cell lines were established. These patients comprised approximately one four
c-myc oncogene is the most extensively studied member of the myc gene family, which now consists of three characterized members, namely the c-myc, N-myc, and L-myc genes. Deregulation owing to amplification and/or rearrangements of the c-myc gene have been described in a variety of human malignancie