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AMPK limits IL-1-stimulated IL-6 synthesis in osteoblasts: Involvement of IκB/NF-κB pathway

✍ Scribed by Kenji Kato; Haruhiko Tokuda; Rie Matsushima-Nishiwaki; Hideo Natsume; Akira Kondo; Yoshiki Ito; Osamu Kozawa; Takanobu Otsuka


Book ID
113528668
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
613 KB
Volume
24
Category
Article
ISSN
0898-6568

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## Abstract Recent studies suggest that sodium arsenite downregulates NF‐κB activity by inhibiting phosphorylation and subsequent degradation of IκBα. Many effects of sodium arsenite are secondary to induction of heat shock proteins. The role of the heat shock response in arsenite‐induced inhibitio