AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes

Stimulation of myofibrillar protein degr

Stimulation of myofibrillar protein degradation and expression of mRNA encoding the ubiquitin-proteasome system in C2C12 myotubes by dexamethasone: effect of the proteasome inhibitor MG-132

✍ Michael G. Thompson; Amanda Thom; Kris Partridge; Karen Garden; Gillian P. Campb 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB 👁 2 views

Addition of the synthetic glucocorticoid, dexamethasone (Dex) to serum-deprived C 2 C 12 myotubes elicited time-and concentration-dependent changes in Nmethylhistidine (3-MH), a marker of myofibrillar protein degradation. Within 24 h, 100 nM Dex significantly decreased the cell content of 3-MH and i