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Amphiregulin Exosomes Increase Cancer Cell Invasion

✍ Scribed by James N. Higginbotham; Michelle Demory Beckler; Jonathan D. Gephart; Jeffrey L. Franklin; Galina Bogatcheva; Gert-Jan Kremers; David W. Piston; Gregory D. Ayers; Russell E. McConnell; Matthew J. Tyska; Robert J. Coffey


Book ID
113563425
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
878 KB
Volume
21
Category
Article
ISSN
0960-9822

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## Abstract We have previously shown that SUM‐149 human breast cancer cells require an amphiregulin (AREG) autocrine loop for cell proliferation. We also demonstrated that AREG can increase epidermal growth factor receptor (EGFR) stability and promote EGFR localization to the plasma membrane. In th