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Amphiphilic Hyperbranched Polymers Containing Two Types of β-Cyclodextrin Segments: Synthesis and Properties

✍ Scribed by Wei Tian; Xiao-Dong Fan; Jie Kong; Yu-Yang Liu; Wei-Hong Zhang; Guang-Wen Cheng; Min Jiang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
730 KB
Volume
210
Category
Article
ISSN
1022-1352

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✦ Synopsis

Abstract

Amphiphilic hyperbranched polymers carrying two types of β‐cyclodextrin groups including ionic and covalent bonding were synthesized via atom transfer radical polymerization and immobilization reaction. Their inclusion capabilities for single or double‐guest molecules were investigated by UV‐visible spectroscopy. Using Chlorambucil and Lonidamine as the double model drugs, their encapsulation efficiencies indicate that these polymers possess the capabilities of high drug‐loading. Furthermore, the release behaviors of these polymers were studied via UV‐visible spectroscopy. The results indicate that they can slow the release rate of double model drugs. Varying the pH values of environment or regulating their shell layer structures can control the release behaviors of double model drugs.

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## Abstract Poly(__N__‐isopropylacrylamide) (PNIPAM) oligomer containing one adamantyl (AD) and two β‐cyclodextrin (β‐CD) moieties at the chain terminals, __AD__‐PNIPAM‐(β‐__CD__)~2~, was synthesized by atom transfer radical polymerization (ATRP) and successive click reactions. In aqueous solution,