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Amphiphilic Cyclodextrin Complexation of Clofazimine

✍ Scribed by Pascale Schwinté; Meera Ramphul; Raphael Darcy; John F. O'Sullivan

Book ID
111589595
Publisher
Springer Netherlands
Year
2003
Tongue
English
Weight
166 KB
Volume
47
Category
Article
ISSN
0923-0750

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Promethazine hydrochloride (PTZ) is an amphiphilic drug derived from the phenothiazine structure that possesses a charged aliphatic chain with a chiral carbon. In the presence of beta-cyclodextrin (beta-CD), this drug undergoes significant changes of its photophysical properties in aqueous solution.