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Amphiphilic Branched Polymers as Antimicrobial Agents

✍ Scribed by Nicolas Pasquier; Helmut Keul; Elisabeth Heine; Martin Moeller; Borislav Angelov; Sebastian Linser; Regine Willumeit

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
389 KB
Volume
8
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Cationic amphiphilic polymers were prepared from PEI and functional ethylene carbonates bearing cationic, hydrophobic or amphiphilic groups. The polymers are designed to exhibit antimicrobial properties. In a one‐step addition, different functional ethylene carbonates were added to react with the primary amine groups of PEI. The water soluble polymers were studied regarding their ability to form soluble aggregates. Their hydrodynamic radii, their inhibition potential against proliferation of E. coli and their hemolytic potential were determined. A structure‐property relationship was established by analyzing the antimicrobial activity as a function of the ratio of alkyl to cationic groups, length of the alkyl chains, and molecular weight of the PEI.

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