Amphiphilic Block-Graft Copolymers with a Degradable Backbone and Polyethylene Glycol Pendant Chains Prepared via Ring-Opening Polymerization of a Macromonomer

✍ Scribed by Xiaojin Zhang; Fujie Chen; Zhenlin Zhong; Renxi Zhuo

• Book ID: 102496687
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 205 KB
• Volume: 31
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.201000392

✦ Synopsis

Abstract

Well‐defined amphiphilic block‐graft copolymers PCL‐b‐[DTC‐co‐(MTC‐mPEG)] with polyethylene glycol methyl ether pendant chains were designed and synthesized. First, monohydroxyl‐terminated macroinitiators PCL‐OH were prepared. Then, ring‐opening copolymerization of 2,2‐dimethyltrimethylene carbonate (DTC) and cyclic carbonate‐terminated PEG (MTC‐mPEG) macromonomer was carried out in the presence of the macroinitiator in bulk to give the target copolymers. All the polymers were characterized by ^1^H NMR and gel permeation chromatography (GPC). The polymers have unimodal molecular weight distributions and moderate polydispersity indexes. The amphiphilic block‐graft copolymers self‐assemble in water forming stable micelle solutions with a narrow size distribution. magnified image