Amphetamine does not affect the partial punishment effect (PPE)
β Scribed by I. Weiner; H. Bercovitz; J. Feldon
- Book ID
- 104716679
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 545 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
β¦ Synopsis
The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in addition, received footshocks of a gradually increasing intensity in the goal box on a random 50% of the trials. In the test stage, all animals received both food and footshock on each trial. dl-Amphetamine 1.5 mg/kg was administered in a 2 X 2 design, i.e. drug-no drug in training and drug-no drug in test. The partially punished animals exhibited increased persitence in running to the goal box during test, and this "partial punishment effect" was unaffected by amphetamine.
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The pre-mRNA processing enhancer (PPE) element is an RNA sequence element derived from the intronless HSV-TK gene. Insertion of the element into the highly intron-dependent human β€-globin gene leads to efficient expression in the absence of splicing. We have analyzed the effect of the PPE element on