AMPA receptor antagonists
✍ Scribed by Chimirri, Alba; Gitto, Rosaria; Zappalà, Maria
- Book ID
- 118012699
- Publisher
- Informa plc
- Year
- 1999
- Tongue
- English
- Weight
- 140 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1354-3776
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## Abstract Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) where it is involved in the physiological regulation of different processes. It has been well established that excessive endogenous Glu is associated with many acute and chronic ne
Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K~ value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected