AMPA Receptor Agonists: Synthesis, Protolytic Properties, and Pharmacology of 3-Isothiazolol Bioisosteres of Glutamic Acid
✍ Scribed by Matzen, Lisa; Engesgaard, Anne; Ebert, Bjarke; Didriksen, Michael; Frølund, Bente; Krogsgaard-Larsen, Povl; Jaroszewski, Jerzy W.
- Book ID
- 120507060
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 288 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2623
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak