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AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

โœ Scribed by Kasibhatla, Srinivas Rao; Bookser, Brett C.; Xiao, Wei; Erion, Mark D.


Book ID
125514893
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
82 KB
Volume
44
Category
Article
ISSN
0022-2623

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โœ Xiaoxiang Zhu; Kamlesh A. Sheth; Shihong Li; Hui-Hwa Chang; Jian-Qiang Fan ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 114 KB ๐Ÿ‘ 1 views

Scheme 1. Synthesis of IFG (1) and IFG derivatives 2-8. a) CH 2 = C(OMe)Me, TsOHโ€ขH 2 O, THF, 1.5 h, 0 8C (53 %); b) Tf 2 O, pyridine, CH 2 Cl 2 , 2 h, ร€78!0 8C; then KCN, 18[crown]-6, DMF, 16 h, RT (80 %); c) RMgX, Et 2 O, 2 h, RT; then NaBH 4 , overnight, RT (65-74 %); d) H 2 , 20 % Pd(OH) 2 /C, Ac