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AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells

✍ Scribed by Lisa Miranda; Sarah Carpentier; Anna Platek; Nusrat Hussain; Marie-Agnès Gueuning; Didier Vertommen; Yurda Ozkan; Brice Sid; Louis Hue; Pierre J. Courtoy; Mark H. Rider; Sandrine Horman

Book ID
116300270
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
548 KB
Volume
396
Category
Article
ISSN
0006-291X

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✍ Jin, Shida ;Shimizu, Miho ;Balasubramanyam, Ashok ;Epstein, Henry F. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 477 KB

DMPK, the product of the DM locus, is a member of the same family of serine-threonine protein kinases as the Rho-associated enzymes. In DM, membrane inclusions accumulate in lens fiber cells producing cataracts. Overexpression of DMPK in cultured lens epithelial cells led to apoptotic-like blebbing