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AMP-activated protein kinase (AMPK) regulates in vitro bone formation and bone mass in vivo

✍ Scribed by M. Shah⁎; A. Bataveljic; T.R. Arnett; B. Viollet; L.K. Saxon; M. Korbonits; C. Chenu

Book ID
116323011
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
61 KB
Volume
47
Category
Article
ISSN
8756-3282

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Recombinant human bone morphogenetic protein-2 (rhBMP-2) was biotinated, and the bioactivity of biotinated protein was assessed in vitro (alkaline phosphate induction in limb bud cells) and in vivo (osteoinduction in the rat ectopic assay). Amino-biotinated rhBMP-2 exhibited an increase in bioactivi