AMP-activated Protein Kinase

✍ Scribed by Mario D. Cordero, Benoit Viollet (eds.)

Publisher: Springer International Publishing
Year: 2016
Tongue: English
Leaves: 518
Series: Experientia Supplementum 107
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes.

This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
Structure and Regulation of AMPK....Pages 3-22
Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK....Pages 23-43
AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics....Pages 45-71
AMPK and Placental Progenitor Cells....Pages 73-79
Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity....Pages 81-126
Front Matter....Pages 127-127
AMPK/Mitochondria in Metabolic Diseases....Pages 129-152
AMPK in Neurodegenerative Diseases....Pages 153-177
AMPK in Cardiovascular Diseases....Pages 179-201
AMPK and Cancer....Pages 203-226
AMPK as a Pro-longevity Target....Pages 227-256
Targeting AMPK for the Alleviation of Pathological Pain....Pages 257-285
AMPK in Pathogens....Pages 287-323
Front Matter....Pages 325-325
Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators....Pages 327-350
Front Matter....Pages 351-351
AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein Kinase Complex....Pages 353-374
5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans ....Pages 375-388
The Role of AMPK in Drosophila melanogaster ....Pages 389-401
Plant SnRK1 Kinases: Structure, Regulation, and Function....Pages 403-438
Front Matter....Pages 439-439
Animal Models to Study AMPK....Pages 441-469
In Vitro Methods to Study AMPK....Pages 471-489
Genetically Encoded Fluorescent Biosensors to Explore AMPK Signaling and Energy Metabolism....Pages 491-523

✦ Subjects

Human Physiology;Medical Biochemistry;Metabolic Diseases

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