Among the human antibodies reacting with intracytoplasmic a particles of mouse mammary tumor virus, some react with MMTV p14, the nucleic-acid-binding protein, and others with MMTV p28, the main core protein
✍ Scribed by Stefan Zotter; Heinz Grossmann; Camille François; Sara Kozma; Pierre Hainaut; Claire-Michelle Calberg-Bacq; Paul M. Osterrieth
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 823 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Human IgG antibodies reacting in the indirect immunofluorescence test with clusters of intracytoplasmic A particles in mouse tissues were analyzed by means of both radioimmunoprecipitation and enzyme‐linked immuno‐absorbant assays. Generally, antibody‐containing sera reacted with epitopes of p14, the nucleic‐acid‐binding core protein of mouse mammary tumor virus, corresponding to the protein Ap14 of intracytoplasmic A particles. Comparatively few sera reacted with epitopes of the main core protein p28 corresponding to the protein Ap28 of intracytoplasmic A particles. The two types of reactivity occurred independently of each other.