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Aminopyrine-induced blood dyscrasias

✍ Scribed by Thomas Y. K. Chan; Anthony W. K. Chan

Book ID
101290270
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
58 KB
Volume
7
Category
Article
ISSN
1053-8569

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✦ Synopsis

Because of the high incidence of agranulocytosis, 1Β±6 the aminopyrines have already been banned or withdrawn from the market in the western countries in the 1960s or 1970s. 7 Unfortunately, these drugs are still available in other parts of the world. 6 Spontaneous reports 7,8 and the results of some 9 but not all 10 epidemiologic studies also suggest an association between aminopyrine use and aplastic anaemia.

The risk of blood dyscrasias in patients receiving aminopyrines is suciently great to render these drugs unsuitable for use, especially when much safer alternatives are available.

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