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Aminoimidazole Carboxamide Ribonucleotide Ameliorates Experimental Autoimmune Uveitis

✍ Scribed by Suzuki, Jun ;Yoshimura, Takeru ;Simeonova, Marina ;Takeuchi, Kimio ;Murakami, Yusuke ;Morizane, Yuki ;Miller, Joan W. ;Sobrin, Lucia ;Vavvas, Demetrios G.

Book ID
111692652
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Year
2012
Weight
551 KB
Volume
53
Category
Article
ISSN
1552-5783

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## Abstract Experimental autoimmune encephalomyelitis (EAE) is a model for studying multiple sclerosis (MS), a chronic demyelinating disorder of the CNS. 5‐Aminoimidazole‐4‐carboxamide ribonucleoside (AICAR), an activator of AMP‐activated protein kinase (AMPK), has been reported to show antiinflamm