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Aminoglycosides: single or multiple daily dosing?

✍ Scribed by A.M. Gallo̸e; L.B. Madsen; N. Graudal; J.P. Kampmann


Book ID
119067386
Publisher
The Lancet
Year
1993
Tongue
English
Weight
190 KB
Volume
341
Category
Article
ISSN
0140-6736

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Aminoglycosides: single or multiple dail
✍ A. M. Galløe; N. Graudal; H. R. Christensen; J. P. Kampmann 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 421 KB

A number of randomised studies indicate that a single high dose of aminoglycoside every 24 h may be more efficient and less toxic than the same dose divided into multiple daily doses. In the meta-analysis of 16 studies described here, which included more than 1200 patients, the relative chance (i.